The Quest to Activate a Commonly Inactive Protective Protein
New research sponsored by the American Heart Association found high levels of a protective protein, albeit an inactive version of the protein, in the blood of African-Americans on dialysis. Matrix Gla protein, or MGP, has high affinity binding to calcium ions and therefore inhibiting vascular calcification. Researchers believe finding ways to activate this protein can lead to lower rates of vascular disease in current dialysis patients. MGP is activated by vitamin K and appears to be the only natural inhibitor of vascular calcification while vitamin K is the only known activator of MGP. Active MGP binds to calcium that circulates in [...]